TY  - JOUR
T1  - Effect of 4-Hydroxycinnamic Acid on Chickens Infected with Infectious Bursal Disease Virus
AU - He, Cheng AU - Pu, Zhonghui AU - Li, Shumei AU - Pan, Qing AU - Hou, Na AU - Zhang, Faming AU - Ou, Changbo 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 17
SP  - 2292
EP  - 2296
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.2292.2296
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.2292.2296
KW  - spleen lymphocytes proliferation
KW  -Fructus mume
KW  -4-hydroxycinamic acid
KW  -infectious bursal disease
KW  -screaning
KW  -spleen
KW  -China
AB  - 4-hydroxycinnamic acid was firstly isolated from Fructus mume and identified to be one of the main components. The studies aimed to investigate the immunotherapeutic potential of 4-hydroxycinnamic acid on SPF chickens infected with IBDV. The results showed that the bird survival rate of 3 dosage groups of 4-hydroxycinnamic acid was 87.5, 62.5 and 42.86%, respectively while body weight gain rate was 25.68, 25.28 and 21.37%, respectively. As for the survival rate and body weight gain, no significant difference was found between 35 mg kg<SUP>-1</SUP> dosage and high immune yolk antibody group (p&gt;0.05). The histopathology score of the high dosage group 3 was lower than that of the high immune yolk antibody group 6. The Stimulate Index (SI) of spleen lymphocytes of chickens fed 4-hydroxycinnamic acid (SI = 1.69) was significantly higher than that of untreated chickens (SI = 1.36) (p&lt;0.05). These results showed that chickens fed with 35 mg kg<SUP>-1</SUP> 4-hydroxycinnamic acid for 5 days could effectively induce a high protection against IBDV and its related mechanism may enhance cell immunity.
ER  -