TY  - JOUR
T1  - Expression Analysis of <I>HIF-1&#945;</I> and <I>HIF-2&#945;</I> Genes in Tibetan Chicken under Normoxia and Hypoxia
AU - Fang, M. AU - Zhang, J.B. AU - Dong, X.X. AU - Bai, Y. AU - Yang, Y.Z. 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 16
SP  - 2172
EP  - 2175
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.2172.2175
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.2172.2175
KW  - hypoxia
KW  -normoxia
KW  -HIF-2a
KW  -HIF-1a
KW  -Tibetan chicken
KW  -adaptability
AB  - Tibetan chicken is one of those chicken breeds that could adapt to high altitude and low O<SUB>2</SUB> tension environment; it owes an integrative genetic mechanism for hypoxia adaptability compared to lowland chicken breeds. HIF-1&#945; and HIF-2&#945; are the central factors playing important roles in maintaining organisms&#146;s oxygen homeostasis. In this study, the expression of <I>HIF-1&#945;</I> and <I>HIF-2&#945;</I> genes were investigated by Real Time-PCR in Tibetan chicken and Dwarf chicken embryo brain tissue under normoxia (21% oxygen concentration) and hypoxia (13% oxygen concentration). The results showed that Tibetan chicken always had lower mortality than Dwarf chicken during the incubation. We also detected higher HIF-&#945;s expression at the late of incubation (18th day) compared with that at 12th day in all tested samples; we further obtained the expression pattern of <I>HIF-&#945;s</I> genes in dead embryos was opposite to that in live embryos.
ER  -