TY  - JOUR
T1  - Polymorphism Identification of<I> IRF6</I> Gene and it Associate with Immune Trait in Three Pig Populations
AU - Cheng, Yuxin AU - Pang, Xunsheng AU - Cai, Zhihua AU - Li, Shenghe AU - Liu, Deyi AU - Wang, Like 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 16
SP  - 2095
EP  - 2098
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.2095.2098
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.2095.2098
KW  - association analysis
KW  -PCR-RFLP
KW  -polymorphism
KW  -IRF6 gene
KW  -Pig
KW  -China
AB  - In this study, researchers chose the Interferon Regulatory Factor 6 (<I>IRF6</I>) gene as a candidate gene to evaluate its effect on porcine immune traits. Using the PCR-RFLP analysis and sequencing, a SNP (HQ026023:1383 G&gt;C) in exon7 of <I>IRF6</I> gene was detected. In addition, a further analysis of SNP genotypes associated with immune traits including IFN-&#947; and IL10 concentrations in serum was carried out in three pig breeds including Large White, Landraces and Chinese indigenous breed Dingyuan Black pig. Results showed that the SNP of <I>IRF6 </I>gene effects on level of IFN-&#947; and IL10 (day 20) in serum presented highly significances (p = 0.0264; p = 0.0238) and as for the ratio of IFN-&#947; to IL10 (day 20) in serum, the p-value was 0.0341 which also achieved a significant level. All the results could possibly indicate that the <I>IRF6</I> gene should be regarded as a molecular marker gene for genetic selection associated with these immune traits in the pig breeding program.
ER  -