TY  - JOUR
T1  - Ghrelin Alleviates Tilmicosin-Induced Myocardial Oxidative Stress in Rats
AU - Boyraz, Ugur AU - Cetin, Nazmi AU - Cetin, Ebru 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 15
SP  - 2038
EP  - 2042
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.2038.2042
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.2038.2042
KW  - Tilmicosin
KW  -Turkey
KW  -myocardial injury
KW  -antioxidant enzyme
KW  -ghrelin
AB  - The aim of this study was to evaluate the possible antioxidant effect of ghrelin against tilmicosin-induced myocardial damage in rats. Forty male Sprague Dawley rats were equally divided into four groups: control (saline for 5 days), tilmicosin (single dose of 75 mg kg&oline;<SUP>1</SUP>, s.c.), ghrelin (10 ng/kg/day for 5 days, s.c.) and ghrelin plus tilmicosin group (pretreatment with ghrelin followed by tilmicosin treatment). The heart were excised for evaluating Malondialdehyde (MDA) content, Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPx) activity. The results showed that tilmicosin treatment alone significantly (p&lt;0.05) elevated the levels of MDA and lowered the activities of SOD, CAT and GPx when compared with the control group. Pretreatment with ghrelin ameliorated the SOD, CAT and GPx activities and inhibited the levels of MDA production in the heart tissue compared to tilmicosin-treated rats. The results of the study provide evidence that the ghrelin pretreatment enhances the antioxidant defense against tilmicosin-induced myocardial oxidative injury in rats and exhibit cardioprotective property.
ER  -