TY  - JOUR
T1  - Polymorphism Identification and Association Analysis of <I>IRF3</I> Gene in Pig
AU - Wang, Like AU - Cai, Zhihua AU - Liu, Deyi AU - Li, Shenghe AU - Pang, Xunsheng AU - Cheng, Yuxin 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 14
SP  - 1841
EP  - 1844
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.1841.1844
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.1841.1844
KW  - China
KW  -Pig
KW  -association analysis
KW  -PCR-SSCP
KW  -polymorphism
KW  -IRF3 gene
AB  - In this study, <I>IRF3</I> gene was chosen as a candidate gene for evaluating its effect on porcine immune traits. A SNP (HQ026024: g.4252T&gt;C) in exon7 of <I>IRF3</I> gene was demonstrated by PCR-SSCP analysis and sequencing. Immune traits including IFN-&#947; and IL10 concentrations in serum were measured when the pigs are at 20th day of age. The further association analysis of SNP genotypes with immune traits were also conducted in 3 pig breeds including Large white, Landraces and Chinese indigenous breed Dingyuan black pig. The results indicated that the SNP of <I>IRF3</I> gene had highly significant effects on level of IFN-&#947; and IL10 (day 20) in serum (p = 0.0344; p = 0.0121) and ratio of IFN-&#947; to IL10 (day 20) in serum (p = 0.0315). The results suggested that the <I>IRF3</I> gene could be regarded as a molecular marker gene for genetic selection of these immune traits in the pig breeding program.
ER  -