TY  - JOUR
T1  - Tryptophan Stimulates Immune Response in Broiler Chickens Challenged with Infectious Bursal Disease Vaccine
AU - Emadi, Mozhdeh AU - Jahanshiri, Fatemeh AU - Kaveh, Kamran AU - Hair-Bejo, Mohd AU - Ideris, Aini AU - Alimon, Razak 
JO  - Journal of Animal and Veterinary Advances
VL  - 9
IS  - 3
SP  - 610
EP  - 616
PY  - 2010
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2010.610.616
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2010.610.616
KW  - Tryptophan
KW  -infectious bursal disease virus
KW  -immune response
KW  -immunity indicators
KW  -broiler chicks
AB  - Infectious bursal disease is still a challenging issue by posing a serious threat to the commercial poultry industry especially due to the emergence of highly Infectious Bursal Disease Virus (IBDV). In the present study, we evaluated the immunomodulatory effects of Tryptophan (Trp) on innate, humoral and cellular immune responses in chickens challenged by oral administration of intermediate plus strain of IBD virus at 28 days of age. A corn-soybean meal based diet containing different levels of Trp (0, 0.10 and 0.20) for the starter, (0, 0.07 and 0.15) for the grower and (0, 0.05 and 0.13) for the finisher has been utilized. In a completely randomized design with three treatments of five replicates each and 10 chickens per replicate, 150 Cobb 500 male broiler chickens from 0-49 days of age were subjected to Trp diet. To measure the innate, cellular and humoral immunity indicators (interferon-α, interferon-γ, immunoglobulin G, respectively) at 27, 35, 42 and 49 days of age, serum samples from each replicate of treatments were collected and subjected to ELISA. The result showed that Trp supplementation in the chickens basal diets significantly increased the serum levels of interferon-α at 35, 42 and 49 days of age (p<0.05), interferon-γ at 27, 35 and 49 days of age (p<0.05) and immunoglobulin G at 27, 35, 42 and 49 days of age (p<0.05). These results strongly suggest that tryptophan plays a vital role in modulation of protective immune response against IBDV.
ER  -