TY  - JOUR
T1  - Effects of Estrogen Replacement Therapy with Vitamin E on Oxidative Stress in Hepatic and Pancreatic Tissues of Ovariectomized Diabetic Rats
AU - Cay, Mehmet AU - Ulas, Mustafa 
JO  - Journal of Animal and Veterinary Advances
VL  - 9
IS  - 23
SP  - 2955
EP  - 2962
PY  - 2010
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2010.2955.2962
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2010.2955.2962
KW  - Ovariectomy
KW  -estrogen
KW  -vitamin E
KW  -MDA
KW  -AST
KW  -ALT
AB  - We investigate the effects of 17&#946;-estradiol (E<SUB>2</SUB>) and vitamin E on oxidative stress of hepatic and pancreatic tissues in Ovariectomized (OVX) diabetic rats. Fortynine rats were equally divided into seven groups: Control; OVX; OVX+E<SUB>2</SUB>; OVX+E<SUB>2</SUB>+Vitamin E; OVX+Diabetic; OVX+Diabetic+E<SUB>2</SUB> and OVX+Diabetic+E<SUB>2</SUB>+Vitamin E. The Glutathione Peroxidase (GSH-Px), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and vitamin A and &#946;-carotene in liver and pancreas were reduced when compared with control but Malondialdehide (MDA) was raised. E<SUB>2 </SUB>and E<SUB>2</SUB>+vitamin E supplementations to OVX rats increased GSH-Px, SOD, CAT, GSH, vitamin A and &#946;-carotene in liver and pancreas but decreased MDA. MDA in liver and pancreas, Aspartate amino Transferase (AST), Alanine amino Transferase (ALT), Lactate Dehydrogenase (LDH), &#946;-glutamyl Transferase (GGT) and Alkaline Phosphatase (ALP) in the serum of diabetic OVX rats were raised when compared with OVX but the activities antioxidant enzyme, GSH, vitamin A and &#946;-carotene in liver and pancreas were lowered. The GSH-Px, SOD, CAT, GSH, vitamin A and &#946;-carotene in liver and pancreas increased, although MDA in liver and pancreas and AST, ALT, LDH, GGT and ALP in serum decreased in diabetic OVX after E<SUB>2</SUB> and E<SUB>2</SUB>+vitamin E supplementation.
ER  -