TY  - JOUR
T1  - Changes in Glycolipid Metabolism During A High-Sucrose Feeding in Spontaneously Diabetic Torii (SDT) Rats, A Genetic Model of Nonobese Type 2 Diabetes
AU - Ohta, Takeshi AU - Miyajima, Katsuhiro AU - Yamada, Takahisa 
JO  - Journal of Animal and Veterinary Advances
VL  - 9
IS  - 22
SP  - 2883
EP  - 2889
PY  - 2010
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2010.2883.2889
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2010.2883.2889
KW  - Diabetes
KW  -high-sucrose diet
KW  -rat
KW  -abnormality
KW  -fatty liver
KW  -serum
AB  - A high-sucrose diet induces insulin resistance and dyslipidemia in normal rats. The purpose of the present study was to investigate the effects of a high-sucrose diet on glycolipid metabolism in Spontaneously Diabetic Torii (SDT) rats, a genetic model of nonobese type 2 diabetes. Male SDT rats were fed with a high-sucrose (68% of energy) diet from 8-24 weeks of age. SDT rats fed a high-sucrose diet showed hypercholesterolemia, hyperinsulinemia and hyperleptinemia but the body weight and the serum triglyceride level were not increased. Unexpectedly in SDT rats fed a high-sucrose diet, we observed a suppress of the incidence of diabetes mellitus. In computed tomography analysis, SDT rats fed a high-sucrose diet showed an increase of visceral or subcutaneous fat tissue weight. In pathological analyses, slight or mild fatty liver was observed by high-sucrose feeding. A high-sucrose diet in SDT rats induced dyslipidemia, insulin resistance and fat storage but not development of diabetes. High sucrose-fed diabetic rats are considered to be useful for further elucidation of complex mechanisms in glycolipid metabolic abnormality.
ER  -