TY  - JOUR
T1  - Nephrocalcinosis and Urinary Mineral Concentrations in Rats Fed Diets Containing Various Concentrations of Magnesium
AU - Mohamed, H.E. AU - Alhaidary, A. AU - Beynen, A.C. 
JO  - Journal of Animal and Veterinary Advances
VL  - 9
IS  - 18
SP  - 2405
EP  - 2408
PY  - 2010
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2010.2405.2408
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2010.2405.2408
KW  - Rats
KW  -nephrocalcinosis
KW  -diet
KW  -urine
KW  -magnesium
KW  -phosphorus
KW  -concentrations
AB  - High magnesium intakes are known to inhibit the development of nephrocalcinosis in female rats but there was no information on the dose-response relationship and the underlying mechanism. In an attempt to collect the lacking information, female rats were fed diets containing 0.02-0.24% magnesium as the only variable. Increasing dietary magnesium concentrations were found to reduce nephrocalcinosis in a dose-dependent fashion. The lowest dietary magnesium level produced a kidney calcium concentration of 10.6% in the dry matter whereas the highest magnesium intake reduced kidney calcium to 0.2%. Increasing dietary magnesium concentrations produced increasing urinary magnesium concentrations in combination with decreasing phosphorus concentrations. It is suggested that the magnesium-induced inhibition of nephrocalcinosis is caused by a decrease in urinary phosphorus and increase in urinary magnesium.
ER  -