TY  - JOUR
T1  - The Effect of Oral Levothyroxine Sodium on Serum Zn, Fe, Ca and Mg Levels During Acute Copper Sulfate Toxication in Rabbits
AU - Karademir, Basaran AU - Eseceli, Huseyin AU - Kart, Asim 
JO  - Journal of Animal and Veterinary Advances
VL  - 9
IS  - 2
SP  - 240
EP  - 247
PY  - 2010
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2010.240.247
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2010.240.247
KW  - Thyroxine
KW  -CuSO4 toxication
KW  -serum
KW  -Cu
KW  -Zn
KW  -Fe
KW  -Ca
KW  -Mg
AB  - This study was carried out to determine the effect of oral levothyroxine sodium (T<SUB>4</SUB>) application on some serum mineral (Zn, Fe, Ca and Mg) concentrations during CuSO<SUB>4</SUB> toxication (1%). Forty male New Zealand rabbits (6 months-old, weighing 2.16&plusmn;0.08 kg) were allocated to 4 groups. All groups received 1% CuSO<SUB>4 </SUB>(*5H<SUB>2</SUB>O) (Copper (II) sulfate pentahydrate M102787) in drinking water. Except for control group (group A), T<SUB>4</SUB> was orally applied to 3 experimental groups at doses of 1.67 (group B), 3.33 (group C) and 6.67 &#956;g kg<SUP>-1</SUP> per bw per day (group D) for 2 days. Serum Cu measurements were performed by Atomic Absorption Spectrometer equipped with Flame system. Serum Zn levels in groups C and D were higher than in group A, while serum Ca levels in groups C and D were found to be lower than in group A (p&lt;0.05), on the last day. There were significant differences for all mineral levels with respect to time (p&lt;0.001). There was also a significant interaction between the dose of T<SUB>4</SUB> applied (groups A-D) and time (p&lt;0.01), except for Fe levels (p&gt;0.05). However, there were significant differences only in Zn and Ca levels in multiple comparisons (p&lt;0.05). A significant correlation was also found between T<SUB>4</SUB> and Zn (r: -0.537, p&lt;0.001) as well as T<SUB>4</SUB> and Ca (r:-0.593, p&lt;0.001) levels. In addition, administration of T<SUB>4</SUB> along with 1% CuSO<SUB>4</SUB> affected serum Zn, Ca and Mg levels significantly (p&lt;0.05). At the result, T<SUB>4</SUB> administration at different doses with 1% CuSO<SUB>4</SUB> caused an increase in serum Zn but a decrease in serum Ca levels. However, the administration of this combination showed no significant effect on serum Fe and Mg levels.
ER  -