TY  - JOUR
T1  - Involvement of the Central Monoaminergic System in Insulin-Induced Anorexia in Chicks
AU - Shiraishi, Jun-Ichi AU - Yanagita, Kouchi AU - Terao, Hiromi AU - Matsuura, Maki AU - Bungo, Takashi 
JO  - Journal of Animal and Veterinary Advances
VL  - 9
IS  - 16
SP  - 2109
EP  - 2112
PY  - 2010
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2010.2109.2112
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2010.2109.2112
KW  - Central nervous system
KW  -insulin
KW  -monoamines
KW  -chicks
KW  -feed intake
KW  -anorexia
AB  - Recent research has revealed the anorexigenic effects of 
  insulin in the central nervous system associated with changes in the expression 
  of hypothalamic neuropeptides such as neuropeptide Y or α-melanocyte stimulating 
  hormone. However, it is possible that monoaminergic system also participates 
  in insulin-induced anorexia in chicks as suggested in early studies which show 
  that changes in monoamine content play important roles in anorexia in mammals. 
  To clarify the role of monoaminergic systems in the anorexic effect of central 
  insulin in neonatal chicks, the levels of brain monoamines after intracerebroventricular 
  injection of insulin were investigated. Although, there were no differences 
  in the levels of adrenalin, 4-hydroxy-3-methoxyphenylacetic acid, serotonin 
  and 5-dihydroxyindole-3-acetic acid at each time point (p>0.1) and the level 
  of noradorenaline in chicks treated with insulin were significantly lower than 
  that with saline at 30 min post-injection (p<0.05). Conversely, dopamine 
  and its metabolite, DOPAC were significantly increased in chicks treated with 
  insulin when compared with the saline control (p<0.01). However, co-injection 
  of dopamine receptor antagonist prolonged insulin-induced anorexia at 60 and 
  120 min post injection (p<0.05). These results indicate that the central 
  noradrenalinergic but not dopaminergic and serotonergic systems may partly be 
  involved in insulin-induced anorexia in neonatal chicks.
ER  -