TY  - JOUR
T1  - The Effects of Epigallocatechin Gallate and N-Acetylcysteine on Mobile Phone-Induced Oxidative Stress in Guinea Pigs
AU - , Gorkem Kismali AU - , Elcin Ozgur AU - , Serkan Sayiner AU - , Burcu Alpaslan AU - , Goknur Guler AU - , Nesrin Seyhan AU - , Tevhide Sel 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 5
SP  - 959
EP  - 961
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.959.961
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.959.961
KW  - Epigallocatechin gallate
KW  -n-acetylcysteine
KW  -oxidative stres
KW  -mobile phone
KW  -guinea pigs
KW  -MDA
AB  - It has been reported that mobile phones induce free radical formation. Epigallocatechin Gallate (EGCG) and N-Acetylcysteine (NAC) were recently found to be potent antioxidants. The present study was carried out to determine the protective effects of antioxidants namely EGCG and NAC against the mobile phone-induced oxidative stress. Three-month-old male Guinea pigs were randomized into 6 groups; sham group, not exposed to mobile phone, NAC group (300 mg kg<SUP>-1</SUP> ip, 7 days), 10 min mobile phone-exposed group with NAC, 10 min mobile phone-exposed group, EGCG group (25 mg kg<SUP>-1</SUP> ip, 7 days) and 10 min mobile phone-exposed group with EGCG. During the exposure external E fields were measured by NARDA EMR 300 and type 8.3 probe. Guinea pigs were exposed to RFR averaged as 11.2&plusmn;0.5 V m<SUP>-1</SUP> for 10 min/day/7days. Malondialdehyde (MDA, an index of lipid peroxidation) were analysed as markers of oxidative stress. Plasma MDA levels increased in mobile phone exposed guinea pigs while EGCG causes a significant reduction of MDA levels, whereas NAC caused a significant increase in MDA levels. Also, MDA levels in mobile phone exposure group significantly increased with respect to sham exposure group. A number of studies have identified antioxidant species which show antioxidant effect in low-dose and pro-oxidant behaviour in high-dose. The increase of the lipid peroxidation at the treatment dose of NAC in guinea pigs may possibly be due to pro-oxidant behaviour. Besides, this study expressed that mobile phone exposure affect the level of lipid peroxidation of plasma.
ER  -