TY  - JOUR
T1  - Effects of Copper and Zinc on Cathepsin B Activity in Equine Articular Chondrocytes
AU - , Gustavo Hernandez Vidal AU - , Jorge R. Kawas Garza AU - , Rafael Ramirez Romero AU - , Luis E. Rodriguez Tovar AU - , Alicia M. Nevares Garza AU - , Francisco A. Mora Valdez AU - , Jesus J. Hernandez Escareno AU - , Elisabeth Davis AU - , Leo B. Jeffcott 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 5
SP  - 935
EP  - 945
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.935.945
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.935.945
KW  - Horse
KW  -cathepsin B
KW  -enzymatic activity
KW  -copper
KW  -zinc
KW  -chondrocytes
KW  -proteoglycan
KW  -articular cartilage and dyschondroplasia
AB  - The effects of copper and zinc on cathepsin B activity, chondrocytes behaviour and matrix turnover by articular cartilage were investigated <I>in vitro </I>using normal horse cartilage co-cultured with synovial tissue. Proteoglycan (PG) depletion was assessed by toluidine blue staining. Co-culture cartilage expressed elevated levels and activity of the PG-degrading enzyme cathepsin B. Copper but not zinc was able to reduce the depletion of PG and the enzyme activity induced by the synovial tissue.
ER  -