TY  - JOUR
T1  - Effects of Soybean Extract and L-Tryptophan on 2, 4-Dichlorophenol Induced Testicular Toxicity in Mice
AU - , Handan Aydin AU - , Alper Baran AU - , Abit Aktas AU - , Kamber Demir AU - , Elif Sahin AU - , Abdullah Kayar AU - , Serhat Pabuccuoglu AU - , Suzan Daglioglu 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 4
SP  - 774
EP  - 778
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.774.778
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.774.778
KW  - Mice
KW  -L-tryptophan
KW  -soybean
KW  -2
KW  -4-dichlorophenol
KW  -abnormal spermatozoa
KW  -toxicity
AB  - Two, 4-Dichlorophenol (2, 4-DCP), an environmental pollutant has been in agriculture and synthetic chemical industry. The aim of present study was to analyse the testicular toxicity of 2, 4-DCP, which caused biochemical, spermatological and histological changes in male mice and to evaluate the possible ameliorative effect of soybean extract and L-Tryptophan (L-TRP). Soybean extract (25 mg/kg bw/day) and L-TRP (150 mg kg<SUP>-2</SUP> bw/day) were given by intraperitoneal (ip) route for 14 days. 2, 4-DCP was administered to male mice with drinking water at dose of 1000 ppm for 14 days. Biochemical parameters in serum ((glucose, creatinine, Blood Urea Nitrogen (BUN), Aspartate Transaminase (AST), Alanine Transaminase (ALT), Lactate Dehydrogenase (LDH)), spermatological and histological changes were investigated at the end of the 14 days comparatively with control group. We conclude that soy extract and L-tryptophan alleviate 2, 4-DCP testicular toxicity.
ER  -