TY  - JOUR
T1  - Effects of Bovine Amniotic Fluid on Acute Corneal Alkali Burns in the Rat
AU - , Ramazan Gonenci AU - , Muhammed Enes Altug AU - , Ahmet Koc AU - , Alper Yalcin 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 4
SP  - 617
EP  - 623
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.617.623
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.617.623
KW  - Alkali burn
KW  -BAF
KW  -bovine amniotic fluid
KW  -cornea
KW  -rat
AB  - </B>Bovine Amniotic Fluid (BAF) was topically applied for treatment group, whereas isotonic saline solution was applied for saline group in the study after an alkali burn was created in the right eye of 16 rats with 2.5 N NaOH. Density and area of the corneal opacity, area of the corneal epithelial defect, corneal neovascularization and complications were clinically evaluated and scored using a modified model at post-injury days 0, 3, 7 and 14. At the end of the experiment, all the eyes were histologically examined after enucleation. It was resultantly found that BAF has slightly decreased corneal opacification, increased reepithelization and limited neovascularization, hyphema and total corneal erosions. But these clinical ocular damage scores were not statistically significant. In histological examination, the number of polymorphonuclear leucocytes, corneal thicknesses, edema, keratinization, vascularization and inflammation were significantly reduced by BAF compared to the saline group. Based on these positive effects in severe burns, it was concluded that BAF could be a new topical alternative agent for veterinary ophthalmology thereafter.
ER  -