TY  - JOUR
T1  - Comparison of Central Effects of L-Ornithine Metabolites on the Stress Responses of Neonatal Chicks
AU - Kurauchi, I. AU - Shigemi, K. AU - Yamada, S. AU - Aoki, M. AU - Kawada, Y. AU - Morishita, K. AU - Denbow, D.M. AU - Furuse, M. 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 12
SP  - 2580
EP  - 2584
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.2580.2584
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.2580.2584
KW  - L-ornithine
KW  -D-ornithine
KW  -L-citrulline
KW  -intracerebroventricular injection
KW  -social separation stress
KW  -neonatal chick
AB  - Recently, we observed that central administration of L-arginine attenuated the stress responses of neonatal chicks by inducing a sedative and hypnotic effect. In addition, L-ornithine, which is produced from L-arginine in the brain, appeared to interact with L-arginine during a stress response. Several putative metabolites from L-ornithine, including L-citrulline and D-ornithine, were therefore investigated in the present study. The effects of intracerebroventricular injection of L-ornithine, L-citrulline and D-ornithine were compared in chicks under an isolation-induced stress. L-ornithine greatly attenuated the stress response and induced sedative and hypnotic effects. D-ornithine weakly attenuated the stress responses, while L-citrulline had no effect.
ER  -