TY  - JOUR
T1  - Polymorphism in 5' Regulatory Region of the Porcine Fat Mass and Obesity Associated (FTO) Gene is Associated with Intramuscular Fat Content in a Jinhua x Pietrain F<sub>2</sub> Reference Population
AU - Li-Fan, Zhang AU - Xiu-Ting, Miao AU - Xu-Chuan, Hua AU - Xiao-Ling, Jiang AU - Yuan-Peng, Lu AU - Ning-Ying, Xu 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 11
SP  - 2329
EP  - 2334
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.2329.2334
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.2329.2334
KW  - Porcine
KW  -regulatory polymorphism
KW  -fat mass and obesity associated gene
KW  -fat deposition
AB  - As a newly described candidate gene in obesity, FTO gene showed a strong and highly significant association with the obesity-related traits in various human populations. It has been suggested that FTO gene play a key role in the regulation of energy balance and feed intake. Here we sequenced the -2.0 kb of the 5' flanking region of the porcine FTO gene, 7 SNPs were detected in this region and genotyped on the Jinhua x Pietrain F<sub>2</sub> reference population. Using a gene-wide haplotype-tagging approach, three tag SNPs were examined. The SNPs of g -1191 A&gt;G had significant associations with Intramuscular Fat (IMF) content (p&lt;0.05), but not with the Average Backfat Thickness (ABF), Leaf Fat weight (LF) or Average Daily Gain (ADG). Additionally, allele frequencies of the g -1191A&gt;G mutation were studied in 6 pig breeds and the G allele was mainly occurred in Chinese native pig breeds. These results provided the solid evidence that FTO gene was associated with the intramuscular fat deposition in pigs.
ER  -