TY  - JOUR
T1  - Oral Administration of Chicken Breast Extract Activates Serotonin Metabolism in the Hippocampus of Rats
AU - Tomonaga, Shozo AU - Sato, Mikako AU - Takahata, Yoshihisa AU - Morimatsu, Fumiki AU - Furuse, Mitsuhiro 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 11
SP  - 2276
EP  - 2279
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.2276.2279
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.2276.2279
KW  - Chicken breast extract
KW  -hippocampus
KW  -serotonin
KW  -5-hydroxyindoleacetic acid
KW  -rats
KW  -micro dialysis
AB  - We previously reported that Chicken Breast Extract (CBEX) had an antidepressant-like effect in rats. In the present study to further clarify, the mechanism of action of CBEX, the effects of CBEX on the brain serotonin (5-HT) system was investigated in the ventral hippocampus of rats, using an <I>in vivo</I> micro dialysis. 5-Hydroxyindoleacetic acid, a major metabolite of serotonin, was significantly increased in animals orally administered CBEX. This result indicates that CBEX may activate 5-HT metabolism in the brain. Since, a previous study indicated that orally administered CBEX increases levels of the putative neurotransmitter carnosine in the hippocampus, carnosine might be involved in the action of CBEX.
ER  -