TY  - JOUR
T1  - Pharmacokinetics and Penetration into the Aqueous Humor of Long Action Oxytetracycline after Single Dose Intravenous and Intramuscular Administrations in Rabbits
AU - Koc, Feride AU - Kaynar, Ozgur AU - Okumus, Zafer AU - Dogan, Elif AU - Yanmaz, Latif Emrah 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 10
SP  - 1900
EP  - 1905
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.1900.1905
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.1900.1905
KW  - Oxytetracycline
KW  -rabbit
KW  -aqueous humor
KW  -pharmacokinetics
KW  -plasma
KW  -intravenous
AB  - The aim of this study was to investigate pharmacokinetics and penetration into the aqueous humor of Long Action Oxytetracycline (OTC-LA) after Intravenous (IV) and Intramuscular (IM) administrations, at a single dose of 20 mg kg<SUP>-1</SUP> b.wt in rabbits. After administrations of the long action formulation, the plasma oxytetracycline concentrations were evaluated using a two-compartmental open model. The study was designed according to a two-period cross-over and the plasma OTC concentration was measured using the ELISA procedure. The elimination half-lives (t<SUB>1/2β</SUB>) of the OTC-LA after IV and IM administrations were 12.60±0.92 and 38.67±4.40 h, respectively. After IV administration, the volume of distribution (V<SUB>dss</SUB>) and total body Clearance (Cl<SUB>tot</SUB>) values of the drug were 3.42±0.21 L kg<SUP>-1</SUP> and 0.19±0.01 L/h/kg, respectively. The maximum concentration of the drug (C<SUB>max</SUB>) in the plasma (4.23±0.43 μg mL<SUP>-1</SUP>) was achieved at 2.0 h (t<SUB>max</SUB>) after IM administration. The Minimum therapeutic plasma Concentration (MIC) of the drug at the amount ≥0.5 μg mL<SUP>-1</SUP> was maintained until 48 h after IV and IM administrations. The intramuscular bioavailability of the drug was 0.79±0.10%. After IV and IM administrations of OTC-LA formulation, the maximum concentrations of the drug in the aqueous humor were 0.1 and 0.068 μg mL<SUP>-1</SUP>, respectively. However, the concentrations of the drug in the aqueous humor were below the MIC value (0.5 μg mL<SUP>-1</SUP>) during 12-72 and 4-48 h for IM and IV administrations, respectively.
ER  -