TY  - JOUR
T1  - Cholinergic Neurotransmission is not Involved in Sedation Induced by L-Proline in Neonatal Chicks
AU - , K. Hamasu AU - , K. Shigemi AU - , Y. Tsuneyoshi AU - , H. Sato AU - , D.M. Denbow AU - , M. Furuse 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 6
SP  - 1207
EP  - 1211
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.1207.1211
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.1207.1211
KW  - L-proline
KW  -acetylcholinesterase
KW  -stress
KW  -intracerebroventricular injection
KW  -neonatal chick
AB  - The aim of the present study was to determine whether the sedative effects of L-proline are associated with the modulation of cholinergic neurotransmission. We investigated the effect of co-injection of L-proline with scopolamine, a Muscarinic Acetylcholine Receptor (M-AChR) antagonist, on behavior of neonatal chicks under isolation-induced stress. Intracerebroventricular (i.c.v.) injection of L-proline reduced spontaneous activity and the number of distress vocalizations, while co-injected scopolamine did not attenuate this effect implying that the M-AChR was not involved in the sedative effects induced by L-proline. In addition, the effect of L-proline on acetylcholineesterase activity in the telencephalon and diencephalon of chicks was investigated. No significant changes in acetylcholineesterase activity were observed in either the telencephalon or diencephalon. These results indicate that the sedative effects induced by L-proline are not mediated by the cholinergic system.
ER  -