TY  - JOUR
T1  - Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia
AU - , Kamil Uney AU - , Ayse Er AU - , Gulcan Erbil Avci AU - , Aziz Bulbul AU - , Muammer Elmas AU - , Enver Yazar 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 5
SP  - 1021
EP  - 1024
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.1021.1024
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.1021.1024
KW  - Tilmicosin
KW  -lipopolysaccharide
KW  -TNF
KW  -IL-1
KW  -IL-10
AB  - The effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 &#956;g,<I> Escherichia coli</I> 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg<SUP>-1</SUP>, subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p&lt;0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.
ER  -