TY  - JOUR
T1  - The Humoral Immun Response of Mice to Liposomes Containing <I>Brucella melitensis </I>Outer Membrane Fragments
AU - , Fatma Kaynak Onurdag AU - , Tuncer Degim AU - , Zelihagul De im AU - , Ismail Kutlu AU - , Ozgur Kaynar AU - , Gulsen Gunes AU - , Ufuk Abbasoglu 
JO  - Journal of Animal and Veterinary Advances
VL  - 7
IS  - 8
SP  - 991
EP  - 995
PY  - 2008
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2008.991.995
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2008.991.995
KW  - Electrolyte balance
KW  -eggshell
KW  -performance
KW  -laying hens
AB  - Brucellosis is an important zoonotic disease and the prevention is made by vaccination of animals. For ewes <I>Brucella melitensis</I> REV-1 live attenuated vaccine is widely used but because of some risks such as being infected during the vaccination, re-infection of animals, a new vaccine with less side effect is need to be improved. In this study it was aimed to determine a strong humoral immune response by encapsulating the <I>Brucella</I> outer membrane antigens with the optimum liposome formulation and the statistical analyses showed that the <I>Brucella</I> outer membrane extract encapsulated with liposome can evoke humoral immune response better than live attenuated <I>B. melitensis </I>REV-1 vaccine in mice.
ER  -