TY  - JOUR
T1  - Effects of Caproic and Caprylic Acids on Microbial Growth and Cytotoxicity
AU - , S.E. Hismiogullari AU - , E. Elyurek AU - , A.A. Hismiogullari AU - , F. Sahin AU - , M. Basalan AU - , S. Yenice 
JO  - Journal of Animal and Veterinary Advances
VL  - 7
IS  - 6
SP  - 731
EP  - 735
PY  - 2008
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2008.731.735
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2008.731.735
KW  - Hexanoic acid
KW  -octanoic acid
KW  -S. aureus
KW  -E. coli
KW  -cytotoxicity
AB  - In order to assess the potential use of fatty acids and their derivatives as alternatives to the regionally banned antibiotics, the bacteriocidal and cytotoxic effects of caproic (hexanoic) and caprylic (octanoic) acids were investigated. Fatty acids at various concentrations were added to media containing <I>Staphylococcus aureus</I>, <I> Escherichia  coli</I>  and  murine  fibroblast  cells. At  0.5%  (w/v) concentration  of &nbsp;hexanoic acid, both <I>S. aureus</I> and <I>E. coli</I> growth occurred, however, octanoic acid was effective on inhibition of growth of both bacteria above 1% level. At the same time octanoic acid above 0.5%, hexanoic acid above 0.25% levels inhibited mammalian cell growth. Both acids decreased the medium pH linearly with increasing concentration. Further investigation is needed to prove that they may be usable for <I>in vivo </I>applications.
ER  -