TY  - JOUR
T1  - Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep
AU - , Samia A.A. Hassan AU - , Sana A.I. Shaddad AU - , A.K. Muddathir AU - , I.B. El-Tayeb AU - , A.O.M. Nour AU - , M.H. Al-Nazawi AU - , A.M. Homeida 
JO  - Journal of Animal and Veterinary Advances
VL  - 7
IS  - 4
SP  - 433
EP  - 436
PY  - 2008
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2008.433.436
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2008.433.436
KW  - Pharmacokinetic
KW  -intramuscular
KW  -long-acting oxytetracycline
KW  -sheep
AB  - The pharmacokinetics of long-acting Oxytetracycline (OTC) formulation (Alamycin-LA) was studied after intramuscular (IM) route at a dose of 1 mg kg <SUP>1</SUP> body weight to fifteen healthy desert sheep. The mean C<SUB>max</SUB> values of 74.8±13.22 µg mL <SUP>1</SUP> was after 0.9±0.13 h, the mean distribution phase was 2.0±0.4 h and the apparent elimination half-life was 126±23 h. The volume of distribution (V<SUB>d</SUB>) was found to be 67.933±4.88 L. The area under the curve (AUC<SUP>0</SUP><SUB>240</SUB>) and the area under concentration-time curve (AUMC) were 2530.26±203.3, 242522.2±48504.5 µg/ml/h<SUP>2</SUP>, respectively. The total body clearance (cl<SUB> </SUB>) was 373.63±18.9 mL h <SUP>1</SUP> while the mean resident time (MRT) was 90.61±13.8 h.
ER  -