TY  - JOUR
T1  - The Use of Propofol as an Anaesthetic Agent in Dogs with Visceral Leishmaniasis
AU - , Nuh Kilic AU - , Serdar Pasa 
JO  - Journal of Animal and Veterinary Advances
VL  - 7
IS  - 10
SP  - 1310
EP  - 1315
PY  - 2008
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2008.1310.1315
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2008.1310.1315
KW  - Propofol
KW  -leishmaniasis
KW  -anaesthesia
KW  -dog
AB  - The objective of this study was to determine the suitability and adverse effects of propofol as an anaesthetic agent in atropine-fentanyl-diazepam premedicated dogs with Visceral Leishmaniasis (VL<SUP>+</SUP>) and to compare it with clinically healthy dogs not infected with Visceral Leishmaniasis (VL<SUP>-</SUP>). Ten  dogs of mixed breed infected by <I>L. infantum</I> (VL<SUP>+</SUP>) and a control group of 10 dogs (VL<SUP>-</SUP>) of mixed breed were used in this study. Dogs were premedicated with atropine sulphate (0.045 mg kg <SUP>1</SUP> subcutaneous) fentanyl (0.02 mg kg <SUP>1</SUP> intravenous) and diazepam (1 mg kg <SUP>1</SUP> intravenous) followed by induction of anaesthesia with 6 mg kg <SUP>1</SUP> of propofol IV. Anaesthesia was maintained with propofol (4-5 mg kg <SUP>1</SUP>) as an intermittent bolus administration. Heart rate respiratory rate and rectal temperature were measured before premedication (baseline) and 5, 10, 15, 20, 25, 30, 45, 60 after induction and 24 h after anaesthesia. Some biochemical and haemalotogical parameters, were measured before premedication (baseline) and 15, 30, 45, 60 min as well as 24 h after anaesthesia. The total amount of propofol in the VL<SUP>+</SUP> group (18.2±3.8 mg kg <SUP>1</SUP>) was significantly lower compared to 24.6±3.4 mg kg <SUP>1</SUP> in the VL<SUP>-</SUP> group (p&lt;0.05). Haemoglobin haematocrit and the number of RBC decreased significantly in both groups at 60 min of anaesthesia (p&lt;0.05 for both groups) and had also returned to baseline 24 h after propofol administration. Propofol seems to be suitable agent for inducing and maintaining a short period of anaesthesia in <I>Leishmania infantum</I> infected dogs premedicated with atropine fentanyl and diazepam. However, haematocrit and haemoglobin concentration should be monitored closely.
ER  -