TY  - JOUR
T1  - Effects of <I>Nigella sativa</I> L. and <I>Urtica dioica</I> L. On the Numbers of Mast Cells in the Thymus, Spleen and Mesenteric Lymph Nodes of Rats with Carbon Tetrachloride Toxicity
AU - , Mecit Yoruk AU - , Turan Karaca AU - , Sema Uslu 
JO  - Journal of Animal and Veterinary Advances
VL  - 6
IS  - 5
SP  - 601
EP  - 605
PY  - 2007
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2007.601.605
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2007.601.605
KW  - Nigella sativa
KW  -Urtica dioica
KW  -thymus
KW  -spleen
KW  -mesenteric lymph node
KW  -mast cell
KW  -carbon tetrachloride
AB  - This study investigated the effects of <I>Nigella Sativa</I> L. (NS) and <I>Urtica Dioica</I> L. (UD) on the number of Mast Cells (MCs) in Carbon tetrachloride (CCl<SUB>4</SUB>)-treated rats. A total of 35 healthy male Sprague-Dawley rats were divided into 5 equal groups. All groups, expect control group, were injected subcutaneously  with  0.8  mL CCl<SUB>4 </SUB>per kg body weight twice a week for 45 days and then CCl<SUB>4</SUB> + UD-treated, CCl<SUB>4</SUB> + NS-treated and CCl<SUB>4</SUB> + UD + NS-treated rats received a daily intraperitoneal injection of 0.2 mL kg <SUP>1</SUP> NS or/and 2 mL kg <SUP>1</SUP> UD oils for 45 days starting on day 46. Thymus, spleen and mesenteric lymph nodes were sampled, stained with 1% aqueous toluidine blue and examined microscopically. The thymus, spleen and lymph nodes of CCl<SUB>4</SUB>-exposed animals contained significantly increased numbers of MCs compared with control group, CCl<SUB>4</SUB> + UD-treated, CCl<SUB>4</SUB> + NS-treated and CCl<SUB>4</SUB> + UD + NS-treated rats (p< 0.05). However, when exposed rats were also treated with UD, NS or UD + NS, a decrease in MCs was observed. These results demonstrate that UD and NS decrease the number of MCs induced by CCl<SUB>4</SUB> in the lymphoid tissues of rats.
ER  -