TY  - JOUR
T1  - Systemic Effects of Sildenafil Citrate on Pregnancy and Perinatal Periods
AU - , P. Sanchez-Aparicio AU - , D. Mota-rojas AU - , R. Ramirez Necoechea AU - , A. Olmos-Hernandez AU - , M. Alonso-Spilsbury AU - , D. Villanueva-Garcia AU - , M.E. Trujillo-Ortega AU - , R. Hernandez-Gonzalez 
JO  - Journal of Animal and Veterinary Advances
VL  - 6
IS  - 2
SP  - 267
EP  - 271
PY  - 2007
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2007.267.271
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2007.267.271
KW  - Sildenafil
KW  -phosphodiesterase inhibitors
KW  -pregnancy
KW  -perinatal
KW  -posterior application
KW  -erectile dys function
AB  - Sildenafil citrate is an orally administered effective treatment for erectile dysfunction; nevertheless administrated in high concentrations produces relaxation of myometrium in pregnant women, thus sildenafil or related molecules may have future potential tocolytic application. In the present review sildenafil mechanism of action, pharmakocinetics and therapeutic use are discussed. Sildenafil is also considered a potent pulmonary vasodilator in pharmacology representing an alternative to neonates during the last month of in utero development. We conclude that studies in animals including metabolic and physiological traits in the fetus and neonates from treated dams with sildenafil in their last third of pregnancy may help to characterize neonate tolerance to asphyxia with posterior application in human perinatology.
ER  -