TY  - JOUR
T1  - Pathological Changes in Mice Experimentally Injected <I>Clostridium chauvoei</I> Toxins
AU - , M.Y. Sugun AU - , H.M. Kazeem AU - , N.D.G. Ibrahim AU - , N.M. Useh AU - , L.B. Tekdek AU - , I. Ajogi 
JO  - Journal of Animal and Veterinary Advances
VL  - 6
IS  - 2
SP  - 234
EP  - 237
PY  - 2007
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2007.234.237
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2007.234.237
KW  - Pathological changes
KW  -mice
KW  -Clostridium chauvoei
KW  -toxins
AB  - Blackleg is an economically important disease of cattle, sheep and other ruminants which is endemic in both developed and developing countries of the world. Toxins and neuraminidase produced by <I>Clostridium chauvoei</I> have been reported to play significant complimentary roles in the pathogenesis of the disease. In this study, the pathological changes caused by exogenous toxins produced following the culture of <I>C. chauvoei </I>at 24 and 48 h respectively were investigated and it was observed that the 24 h toxin produced more severe pathological changes, compared to the 48 h toxin. Necrosis was observed in the tissues examined, both grossly and histopathologically and was attributed probably to impaired cellular (mitochondrial) respiration. It was concluded that, although toxins produced by <I>C. chauvoei </I>play an important role in the mechanisms of blackleg, the role of leukotrienes (C4, D4 and E4), cytokines (interleukin-1, IL-1; tumour necrosis factor- , TNF- ), platelet-activating factor, interferon, complement fragments (anaphylatoxins C5a and C3a), prostaglandins and neuraminidase in the pathogenesis of <I>C. chauvoei</I> infection in mice need to be thoroughly investigated.
ER  -