TY  - JOUR
T1  - Relationships Between Plasma Cortisol, Corticosteroid-binding Globulin 
(CBG) and The Free Cortisol Index (FCI) In Pigs Over A 24 h Period
AU - , Rebecca J. Adcock AU - , Henry G. Kattesh AU - , Mary P. Roberts AU - , Arnold M. Saxton AU - , Jeffery A. Carroll 
JO  - Journal of Animal and Veterinary Advances
VL  - 5
IS  - 1
SP  - 85
EP  - 91
PY  - 2006
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2006.85.91
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2006.85.91
KW  - Pig
KW  -cortisol
KW  -Corticosteroid-Binding Globulin (CBG)
KW  -Free Cortisol Index (FCI)
AB  - The relationship between plasma free cortisol and the free cortisol index (FCI, the ratio of cortisol to CBG) was evaluated in eight 8-wk old pigs over a 24 h period and in response to administration of saline or ACTH. A high (p<0.001) correlation was found between actual free cortisol and the FCI in both saline (r = 0.73) and ACTH (r = 0.85) treated pigs. A diurnal rhythm was apparent for total cortisol, free cortisol, percent free cortisol, pCBG and the FCI. Total cortisol (p<0.05), free cortisol (p<0.05) and the FCI (p<0.01) were elevated during the first four h following administration of ACTH. Concentrations of pCBG differed (p<0.001) over time and were higher (p<0.01) for ACTH treated pigs over the 24 h period. The results from this study affirm the contention that FCI is a suitable estimate of free cortisol in swine.
ER  -