TY  - JOUR
T1  - Effect of Antibodies Raised in Bovine and Guineapigs on The Genetic Characters of Seroytpe Asia1 FMD Virus
AU - , R. Manoj Kumar AU - , A. Sanyal AU - , D. Hemadri 
JO  - Journal of Animal and Veterinary Advances
VL  - 5
IS  - 4
SP  - 294
EP  - 297
PY  - 2006
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2006.294.297
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2006.294.297
KW  - FMD virus
KW  -antibodies
KW  -genetic characters
AB  - In the present work, the effect of antibodies (raised in Bovine against IND 63/72 and in Guineapigs
against IND 63/72 and IND 491/97) on foot-and-mouth disease serotype Asia1 vaccine strain IND 63/72 was
compared by analyzing the data obtained in nucleotide sequencing. The Nr viruses (neutralization resistant
viruses) which were selected by growing them in the presence of antibodies (Bovine Vaccinate Serum, BVS and
Guineapig Serum, GPS) showed certain characteristic features like common changes in the structural protein
coding P1 region of this virus. This shows that the virus responds equally to the antibodies raised in both
bovine (natural host) and guineapig (experimental host). The result hereIn extends the finding that selection
exerted by host antibody also plays a major role in the rapid evolution of FMD Virus serotype Asia1.
ER  -