TY  - JOUR
T1  - Anticomplementary Activities of Aqueous Extracts of the Fruits of <I>Melia azedarach</I> and <I>Cotoneaster prostratae</I> in Rats
AU - , M. SH. Rhaymah 
JO  - Journal of Animal and Veterinary Advances
VL  - 5
IS  - 3
SP  - 197
EP  - 199
PY  - 2006
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2006.197.199
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2006.197.199
KW  - Aqueous fruit extract
KW  -melia azeda
KW  -anticomplementary
AB  - The effects of<I> </I>aqueous fruit extracts of<I> Melia azedarach</I> (Meliaceae) and <I>Cotoneaster prostratae</I> (Rosaceae) on rat complements were examined. Both extracts showed significant anticomplementary activities on rat serum in both classical and alternative pathways. The effect was more pronounced in classical than alternative pathway. The IC 50% obtained for <I>M. azedarach</I> and <I>C. prostrata</I>e in the alternative pathway was 31.2  and  1.9  mg mL <SUP>1</SUP>, respectively, whereas IC 50% recorded in the classical pathway was 7.8 mg mL <SUP>1</SUP> for <I>M. azedarach</I> and 0.9 mg mL <SUP>1</SUP> for the <I>C. prostratae</I>. Although both extracts were capable of inhibiting complement activity, total inhibition was achieved at higher <I>M. azedarach</I> extract concentrations when compared with those of <I>C. prostrata</I>e extract.
ER  -