TY  - JOUR
T1  - Chiral Inversion of R-(-)-Fenoprofen Enantiomer in Cats with Toxic Hepatic Disease
AU - , Castro, E. AU - , A. Soraci AU - , O. Tapia AU - , F. Fogel AU - , R. Franci AU - , L. Denzoin AU - , I. Ortega 
JO  - Journal of Animal and Veterinary Advances
VL  - 5
IS  - 3
SP  - 176
EP  - 183
PY  - 2006
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2006.176.183
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2006.176.183
KW  - Fenoprofen
KW  -cats
KW  -enantioselective
KW  -chiral inversion
KW  -carbon tethrachloride
AB  - The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl<SUB>4</SUB>). The percentage of chiral inversion in animals with THD was 90.5±21.1 (mean±sd) and the difference with healthy animals was not statistically significant.
ER  -