TY  - JOUR
T1  - Protective Effect of <I>Spirulina platensis</I> Against Lead Toxication in Rats
AU - , Ali Karadeniz AU - , Mustafa Cemek 
JO  - Journal of Animal and Veterinary Advances
VL  - 5
IS  - 12
SP  - 1113
EP  - 1116
PY  - 2006
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2006.1113.1116
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2006.1113.1116
KW  - Spirulina platensis
KW  -lead
KW  -oxidant
KW  -antioxidant
KW  -rat
AB  - It is known that <I>spirulina</I> is rich from the point of view of vitamin, mineral, essential fatty acids and antioxidants such as caretinoids. In this study, the changes on oxidant and antioxidant system occured by <I>spirulina</I> and protective effect of <I>spirulina</I> against lipid peroxidation in lead toxication in rats are examined. Forty adult female wistar albino rats were divided into four experimental groups: control, <I>spirulina</I>, lead and <I>spirulina</I> + lead-treated. At the end of the experimental period (1 month), animals in all four groups were fasted for 12 h and blood samples were taken for the determination malondialdehyde (MDA), reduced glutathione (GSH), ascorbic acid, nitrate and nitrite levels. There was a statistically significant difference between the groups for all parameters except for serum ascorbic acid. It is determined that there was a crucial increase in the level of GSH belonging to <I>spirulina</I> treated group when compared with control group, lead treated group and <I>spirulina</I> + lead treated group (p&lt;0,05). It was observed that the lecvel of MDA which is an important sign of lipid peroxidation for lead treated group is statistically crucial when compared with control group and <I>spirulina</I> treated group when compared with the other groups and this increase is statistically important (p&lt;0.05). Morover, it is seen that there is an increase in the level of nitrate and nitrite for <I>spirulina</I> treated group when compared with the other groups and this increase is statistically important (p&lt;0.05). Consequently, it is indicated that lipid peroxidation occured an animals treated by lead is prevented by the future of antioxidant of <I>spirulina platensis</I> and therefore it assists the level of antioxidants in circulation.
ER  -