TY  - JOUR
T1  - Oral Administration of Lasalocid Causes Peripheral Neuropathy in Sprague Dawley Rats:Effect of Water Salinity on Lasalocid-induced Peripheral Neuropathy
AU - , Asim Kart AU - , Stanley Leon Vanhooser AU - , Subbiah Sangiah 
JO  - Journal of Animal and Veterinary Advances
VL  - 4
IS  - 8
SP  - 719
EP  - 722
PY  - 2005
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2005.719.722
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2005.719.722
KW  - Lasalocid
KW  -ataxia
KW  -neurotoxicity
KW  -heat stress
KW  -salinity
AB  - Lasalocid toxicity was associated with several neurotoxicity cases in animal species. Incidence of lasalocid neurotoxiciy shows a higher rate in chickens during heat stress with increased water salinity. In the present study, It studied the effect of lasalocid with or without 0.9 % NaCl in male Sprague Dawley. The rats were given 0, 10, 20, 40 mgkgG of lasalocid two times a day for 3 days with or without 0.9 % saline in the 1 drinking water. Rats showed ataxia in the 20 and 40 mgkgG dose groups with higher death rate in group 1 receiving 40 mgkgG of lasalocid. Dietary salt did not affect ataxia induced by lasalocid. While the optimum dose 1 to produce ataxia (without high mortality) appears to be 20 mgkgG of lasalocid, increasing salinity of water has 1 no effect on the neurotoxicity of lasalocid.
ER  -