@article{MAKHILLVR20158428056,
    title = {Effects of Different Doses of Viper Cerastes cerastes Crude Venom on the Serum and Some
Enzyme Activities in Male Guinea Pigs at Different Times},
    journal = {Veterinary Research},
    volume = {8},
    number = {4},
    pages = {37-44},
    year = {2015},
    issn = {1993-5412},
    doi = {vr.2015.37.44},
    url = {https://makhillpublications.co/view-article.php?issn=1993-5412&doi=vr.2015.37.44},
    author = {Muhammad},
    keywords = {Viper Cerastes cerastes venom,biochemical parameters,enzyme activities,guinea pigs,post-injection,triglycerides},
    abstract = {The desert horned vipers (<i>C. cerastes</i> and<br>
<i>C. gasperettii</i>) are the most familiar snakes of the great<br>
deserts of North Africa and the Middle East. In the<br>
present study, the effects of Cerastes crude venom on<br>
serum biochemical parameters of Guinea pigs. Female<br>
Guinea pigs (300&plusmn;30 g B.W.) were divided into three<br>
groups (10 each). In the control group, Guinea pigs were<br>
interaperitoneally (ip) injected with 100 &mu;L saline<br>
solution. The second group was ip., injected with<br>
0.2 &mu; g<sup>&#150;1</sup> B.W. of crude venom in 100 &mu;L saline solutions.<br>
The third group was ip., injected with 0.4 &mu;gm g<sup>&#150;1</sup><br>
B.W. of crude venom in 100 &mu;L saline solution. The<br>
results indicated that the single dose of crude venom<br>
induced a significant decrease in total serum protein,<br>
albumin, globulin cholesterol, triglycerides and uric acid<br>
within 12 and 24 h. After injection of crude venom<br>
of the viper C. cerastes. However, the levels of glucose,<br>
urea, creatinine, Alanine aminotransferase (ALT),<br>
Aspartate aminotransferase (AST) and Alkaline<br>
Phosphatase (ALP) were elevated in envenomated Guinea<br>
pigs after 12 and 24 h post-injection of crude venom.<br>
Viper C. cerastes crude venom caused hepatic and renal<br>
dysfunction in envenomated Guinea pigs. These<br>
disturbances are remaining for 24 h after envenomation of<br>
Guinea pigs at least, regardless the using dose.}
    }