@article{MAKHILLRJPS20158327894,
    title = {Calciotropic Principle of <i>Solanum glaucophyllum</i> in Broiler Chickens},
    journal = {Research Journal of Poultry Sciences},
    volume = {8},
    number = {3},
    pages = {28-31},
    year = {2015},
    issn = {1993-5285},
    doi = {rjpscience.2015.28.31},
    url = {https://makhillpublications.co/view-article.php?issn=1993-5285&doi=rjpscience.2015.28.31},
    author = {M.,S.,F.,B. and},
    keywords = {Solanum glaucophyllum,poultry,broiler chickens; 1.25 dihydroxyvitamin D3-glycoside,1.25 dihydroxyvitamin D3},
    abstract = {<i>Solanum glaucophyllum</i> (duraznillo blanco)
which causes calcinosis of cattle in Argentina, contains
the active metabolite of vitamin D<sub>3</sub> either free or
conjugated with carbohydrates as 1.25-(OH)<sub>2</sub> Vitamin
D<sub>3</sub>-glycoside. Economic relevance of <i>S. glaucophyllum</i>
could be seen as being the causal factor of toxicosis of
grazing cattle and also as a valuable source of Vitamin D<sub>3</sub>
active metabolites. Some pharmacological applications in
human and veterinary medicine as well as in animal
husbandry have been assayed. The calciotropic principle
was thought to be the main active metabolite of vitamin
D<sub>3</sub>, once liberated from its glycoside. However,
calciotropic activity of this glycoside seems to be feasible.
In order to know the fate of the water soluble calciotropic
principle of <i>Solanum glaucophyllum</i> administered orally
to broilers, 1,25-(OH)<dub>2</sub>Vitamin D and 1.25-(OH)<sub>2</sub>Vitamin
D<sub>3</sub>-glycoside plasma levels were assayed over a period of
24 h after a unique administration of the aqueous extract
of the plant. Here we show that 1.25(OH)<sub>2</sub> vitamin D
plasma levels did not increase while 1.25 (OH)<sub>2</sub> Vitamin
D<sub>3</sub>-glycoside rapidly appeared in blood, remained in
circulation during the 1st 6 h and was undetectable 24 h
after a unique oral administration of <i>S. glaucophyllum</i>
(0.11 g DM kg<sup>-1</sup> BW), to finishing broilers.}
    }