@article{MAKHILLRJANS20126427705,
    title = {Trial of <I>Aspergillus fumigatus</I> Vaccine in Broiler Chicks},
    journal = {Research Journal of Animal Sciences},
    volume = {6},
    number = {4},
    pages = {72-75},
    year = {2012},
    issn = {1993-5269},
    doi = {rjnasci.2012.72.75},
    url = {https://makhillpublications.co/view-article.php?issn=1993-5269&doi=rjnasci.2012.72.75},
    author = {Clara N.,Jarlath U.,Haruna M. and},
    keywords = {Aspergillosis,aflatoxin,aspergillus,poultry,vaccine},
    abstract = {There is a scarcity of information on the effect of vaccine against aspergillosis in Zaria and Kaduna areas. Thus, this study was conducted to determine the efficacy of an <I>Aspergillus fumigatus</I> germling vaccine. The methodologies used in this study included Aspergillus spore production, determination of LD<SUB>50</SUB>, preparation of the germling vaccine and testing the efficacy on broiler chicks. Three groups of 4 days old broilers were exposed to 4.2-5.8x10<SUP>8</SUP> cfu g<SUP>-1</SUP> lung tissue of <I>A</I>. <I>fumigatus</I>. The calculated amount of <I>A</I>. <I>fumigatus </I>that killed 50% of the broilers was 5.8x10<SUP>7.4</SUP>. <I>A. fumigatus</I> was recovered 4 weeks post exposure. A germling vaccine of <I>A. fumigatus </I>was administered to 4 days old broilers using the ocular route. The trial vaccine showed 40% protection when administered to chicks 2 weeks prior to challenge with <I>A. fumigatus </I>spores. It is recommended that levels of <I>A. fumigatus</I> spores should not rise to 5.8x10<SUP>7.4</SUP> cfu g<SUP>-1</SUP> lung tissue in poultry houses. Adjuvants can be added to the vaccine to raise the level of protection using different routes of administration and vaccinating at an older age.}
    }