@article{MAKHILLJEAS2019142218619,
    title = {Effectiveness of <em>Allium sativum</em> L. Ethanol Extract on the Growth of
<em>Trichophyton rubrum, Trichophyton mentagrophytes, Candida
albicans</em> and <em>Candida tropicalis</em>},
    journal = {Journal of Engineering and Applied Sciences},
    volume = {14},
    number = {22},
    pages = {8420-8424},
    year = {2019},
    issn = {1816-949x},
    doi = {jeasci.2019.8420.8424},
    url = {https://makhillpublications.co/view-article.php?issn=1816-949x&doi=jeasci.2019.8420.8424},
    author = {Leka,Erfan,Ratih,Rifqoh,Dhania and},
    keywords = {Trichophyton mentagrophytes,Trichophyton rubrum,Allium sativum L.,Candida albicans and Candida tropicalis antifungals},
    abstract = {Treatment of <em>Trichophyton </em>sp. and <em>Candida</em> sp. infections can do with various antifungal drugs, one
of which is <i>Allium sativum</i> L. This herb contains Allicin, flavonoids, tannins, saponins and essential oils that
function as antifungals. The research objective was to compare the effectiveness of <i>Allium sativum</i> L. ethanol
extract on the growth of <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Candida albicans</i> and <i>Candida tropicalis</i>. Type of experimental research with the design of the post-test only control group design. The
independent variable was the concentration of ethanol extract of <i>Allium sativum</i> L. and the dependent variable
growth of <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Candida albicans</i> and <i>Candida tropicalis</i>.
The statistical test used was Mann-Whitney. Antifungal activity test was carried out by liquid dilution method
with a concentration of 2.5, 5, 7.5, 10, 12.5, 14, 15, 16, 17.5, 18, 20, 22, 24, 26 and 28 mg/mL the results showed
that Minimum Inhibitory Concentration (MIC) against <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>,
<i>Candida albicans</i> and <i>Candida tropicalis</i> were 17.5, 5, 16 and 20 mg/mL Minimum Bactericidal Concentration
(MBC) results against <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Candida albicans</i> and <i>Candida tropicalis</i> are 20, 7.5, 18 and 22 mg/mL. Based on the Mann-Whitney <i>Trichophyton rubrum</i> and Trichophyton
mentagrophytes test, a synergistic value of 0.037 (p&lt;0.05) obtained at a concentration of 7.5 mg/mL up
to 15 mg/mL. <i>Candida albicans</i> and <i>Candida tropicalis</i> a significance value of 0.037 (p&lt;0.05) at a
concentration of 18 mg/mL.}
    }