@article{MAKHILLIJTM202015420011,
    title = {Evaluation of <i>Zingiber officinale<i/> Effects on Rifampicin Pharmacokinetic Parameters using
Animal Model},
    journal = {International Journal of Tropical Medicine},
    volume = {15},
    number = {4},
    pages = {84-90},
    year = {2020},
    issn = {1816-3319},
    doi = {ijtmed.2020.84.90},
    url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2020.84.90},
    author = {Ayogu,Amorha,Okpalaoka and},
    keywords = {Pharmacokinetics,ginger,rifampicin,concentration,treatment},
    abstract = {The effect of ginger extract on the
pharmacokinetic parameters of rifampicin and its
penetration into the lung was investigated. Albino rats
were used, Group A received rifampicin 10 mg kg<sup>&#150;1</sup> alone
orally; Group B and C received 5 and 10 mg kg<sup>&#150;1</sup> of
ginger extract respectively for 10 days and on day
11, 10 mg kgG1 rifampicin was given as in Group A.
Blood samples were collected at different time and
assayed to determine the concentration of rifampicin in
the lungs tissues. Treatment with 5 mg kg<sup>&#150;1</sup> ginger
significantly (p<0.05) increased T<sub>max</sub> by 93% and
decreased C<sub>max</sub>, AUC, C<sub>L</sub> and t<sub>1/2</sub> by 18, 13, 72 and 33%,
respectively while 10 mg kg<sup>&#150;1</sup> resulted in a nonsignificant
(p>0.05) increase in T<sub>max</sub> by 7% and decreased
C<sub>max</sub>, AUC, t<sub>1/2</sub> and C<sub>L</sub> by 8, 5, 59 and 77%. Concurrent
administration of ginger and rifampicin resulted in
significant (p>0.05) decrease in the concentration of
rifampicin that penetrated the lung from 14.63&timesmn;4.06 in
rifampicin alone to 9.99&plusmn;4.06 and 9.14&plusmn;0.97 for 5 and
10 mg kg<sup>&#150;1</sup> ginger. This study has shown that ginger
caused significant change in the pharmacokinetic
parameters of rifampicin when taken concurrently and
also decreased concentration of rifampicin in the lungs.}
    }