@article{MAKHILLIJTM201712319969,
    title = {Increased Risk and Severity of Pre-Eclampsia among Peri-Urban Women in
Kinshasa Province, Democratic Republic of Congo: The Role of
Nutritional Transition, Obesity and Dyslipidemia},
    journal = {International Journal of Tropical Medicine},
    volume = {12},
    number = {3},
    pages = {29-34},
    year = {2017},
    issn = {1816-3319},
    doi = {ijtmed.2017.29.34},
    url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2017.29.34},
    author = {Oladele Vincent,Charles Bitamazire,Benjamin,Victor Nzuzi,Achille Kitambala,Moise Mvitu,Mireille Solange Nganga,Christophe Masiala,Roland,Emmanuel Mabiala and},
    keywords = {Cardiovascular diseases,dyslipidaemia,obesity,pre-eclampsia,Democratic Republic of Congo,population},
    abstract = {This study assessed the risk and severity of pre-eclampsia associated with obesity and dyslipidemia
in a peri-urban population of Kinshasa Province, Democratic Republic of Congo (DRC). This case control study
recruited 200 participants with preeclampsia as cases and 150 age-matched pregnant women without
preeclampsia as controls at the LOMO Medical Centre, Kinshasa. Waist circumference, systolic and diastolic
blood pressure, carotid intima-media thickness, serum lipids, C-peptide and Homeostasis-Insulin Resistance
Index (HOMA-IR) were measured. There was a significant positive correlation between preeclampsia severity
and most markers of metabolic syndrome with biologic gradient. The means±SD for controls, participants with
mild and severe pre-eclampsia, respectively were: BMI (kg/m<sup>2</sup>) 22.2&plusmn;5.5, 24.1&plusmn;5.7 and 25.6&plusmn;6.0, p&lt;0.0001; Total
cholesterol (mg/dL) 105.0&plusmn;56.8, 153.6&plusmn;63.1 and 173.3&plusmn;60.1, p&lt;0.0001; LDC (mg/dL) 107.3&plusmn;3.4, 112.2&plusmn;4.7 and
122.6&plusmn;3.5, p = 0.006; TNF-&alpha; (ng/L)101.8&plusmn;4.8, 103.1&plusmn;6.6, 137.7&plusmn;5.2 p&lt;0.0001; HOMA-IR (mg/dL) 7.3&plusmn;0.9,
8.3&plusmn;1.1 and 11.3&plusmn;0.7, p&lt;0.0001. There was a negative correlation between pre-eclampsia severity and HDL
(mean&plusmn;SD mg/dL) controls: 41.5&plusmn;3.2, mild pre-eclampsia: 42.4&plusmn;4.7 and severe pre-eclampsia: 29.4&plusmn;2.4,
p = 0.003. High BMI increases the risk and severity of pre-eclampsia which may increase the risk of subsequent
chronic cardio-metabolic diseases in the mothers. Contrary to other studies, LDL was elevated among
pre-eclampsia women in the study population.}
    }