@article{MAKHILLIJTM20116519827,
    title = {Immunoglobulin G Subclass Responses to <I>Plasmodium falciparum</I> Circumsporozoite Protein among Nigerian Children},
    journal = {International Journal of Tropical Medicine},
    volume = {6},
    number = {5},
    pages = {100-105},
    year = {2011},
    issn = {1816-3319},
    doi = {ijtmed.2011.100.105},
    url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2011.100.105},
    author = {Adesoji Adedapo and},
    keywords = {sporozoite,malaria,circumsporozoite protein,antigen,Plasmodium falciparum,Immunoglobulin G subclass},
    abstract = {The response of Immunoglobulin G (IgG) subclass to <I>Plasmodium falciparum</I> Circumsporozoite Protein (CSP)-R32tet32 was evaluated among febrile Nigeria children aged 2-10 years (n = 23) by the Enzyme Linked Immunosorbent Assay (ELISA). The mean absorbance of normal IgG subclass and anti-CSP specific antibody of each subclass was negatively correlated and was significant for IgG3 (r = - 0.358, p = 0.05) and IgG4 (r = - 0.403, p = 0.03). The predominant anti-CSP antibodies were IgG1 and IgG3, co-expressed in nearly 60% of the subjects. Cytophilic IgG1 and IgG3 were associated with positive recognition of the CSP antigen (Fisher&#146;s exact probability test: p = 0.0001). Some 34.78% of the children did not produce any anti-CSP specific antibodies despite previous exposure to sporozoite inoculation. This study demonstrates that cytophilic IgG subclasses are the main antibodies produced against the CSP but some children living in a holoendemic malaria transmission area may not produce anti-CSP specific antibodies. There is a need to investigate the antibody response of this group of children with the CSP based RTS, S/AS vaccine candidate molecules.}
    }