@article{MAKHILLIJTM20083219748,
    title = {Comparative <I>in vitro </I>Activity of Some Macrolide (Erythromycin, Clarithromycin and Azithromycin) and Fluoroquinolone (Ciprofloxacin and Ofloxacin) Antibiotics Against <I>Bacillus anthracis</I>},
    journal = {International Journal of Tropical Medicine},
    volume = {3},
    number = {2},
    pages = {36-39},
    year = {2008},
    issn = {1816-3319},
    doi = {ijtmed.2008.36.39},
    url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2008.36.39},
    author = {J. Ngbede,E.B. Ogundeji,D.A. Nyam and},
    keywords = {Fluroquinolones,macrolides,B. anthracis,in vitro activity,antibiotics},
    abstract = {<I>In vitro</I> activity of three members of the macrolide group of antibiotics (Erythromycin, Clarithromycin and Azithromycin) and two members of the fluoroquinolone group of antibiotics (Ciprofloxacin and Ofloxacin) were  assessed  against <I> Bacillus  anthracis</I>  by  standard  tube  dilution  method.  All  the  isolates  showed varied  susceptibility  to  the  2  groups  of  antimicrobial  agents.  The  isolates  were  susceptible  to Ciprofloxacin (MIC<SUB>50</SUB>-0.78 µg mL <SUP>1</SUP>) and Ofloxacin (MIC<SUB>50</SUB>-0.31 µg mL <SUP>1</SUP>) but were resistant to Erythromycin ((MIC<SUB>50</SUB>-25 µg mL <SUP>1</SUP>), Clarithromycin ((MIC<SUB>50</SUB>-31.25 µg mL <SUP>1</SUP>) and Azithromycin ((MIC<SUB>50</SUB>-200 µg mL <SUP>1</SUP>). Comparing the results  of  the  2  groups  of  antibiotic  susceptibility  tests,  we do not recommend the use of any of the 3 macrolide antibiotics tested for prophylaxis or therapy of <I>B. anthracis </I>in our geographical area, except with specific result of susceptibility test on the particular isolate(s). Ofloxacin is highly recommended as a good alternative to ciprofloxacin antibiotic.}
    }