@article{MAKHILLIJTM20061419705,
    title = {Therapeutic Effect of <I>Aristolochia bractealata</I> Extract Against Experimental <I>Trypanosoma evansi</I> Infection},
    journal = {International Journal of Tropical Medicine},
    volume = {1},
    number = {4},
    pages = {170-172},
    year = {2006},
    issn = {1816-3319},
    doi = {ijtmed.2006.170.172},
    url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2006.170.172},
    author = {H.A.R. Samia,K.H. Elmalik and},
    keywords = {Aristolocjia,infection rats,cholorofomic,typanocidal},
    abstract = {<I>Aristolochia bracteolata</I> of the family Aristolochiaceae, which was reported in the treatment of malaria and sleeping sickness, was evaluated for its <I>in vivo</I> activity against <I>Trypanosoma evansi</I> infection in rats.  Six groups of 10 rats each aged 5-7 weeks, average weight 150 grams were used.  The plant extract was administered orally at dose rates of 250 and 500 mg kg<SUP>-1</SUP> BW for both the chloroformic and methanolic extract.  The activity was compared to Cymelarsan which was given at a dose rate of 2.5 mg kg<SUP>-1</SUP> BW subcutanously.  Results showed that the plant extract gave a promising trypansocidal effect.  The chloroformic extract gave better result than that of the methanolic extract with both doses.  Its use as a new trypanocidal preparation needs further work to identify the bio-active agent(s).}
    }