@article{MAKHILLRJP202014312529,
    title = {Development of Low Dose Eszopiclone Drug Formulation by Using Geometric Blending
Method},
    journal = {Research Journal of Pharmacology},
    volume = {14},
    number = {3},
    pages = {44-48},
    year = {2020},
    issn = {1815-9362},
    doi = {rjpharm.2020.44.48},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9362&doi=rjpharm.2020.44.48},
    author = {Kübra,Cüneyt and},
    keywords = {Geometric blending,low-dose active ingredients,homogeneous distribution,Eszopiclone,insomnia},
    abstract = {Eszopiclone is a type of medicine used in the
treatment of insomnia with a hypnotic effect. The aim of
this study is to create Eszopiclone 3 mg tablet formulation
by providing homogeneous distribution of Eszopiclone
raw material which is found in low amount in the drug,
into the Excipients. In order to achieve homogeneous
blending, 4 trial production and pilot studies were carried
out using the geometric blending and elimination method.
Trial 4 was optimized and the process validation study
was approved. Acceptable content uniformity values of
trial 4 and pilot study were calculated as 8.63 and 8.74%,
respectively. In this study, the importance of geometric
blending and elimination method is shown.}
    }