@article{MAKHILLRJP20126512481,
    title = {Antioxidant, Analgesic and Anti-Inflammatory Activities of <I>Nymphaea Nouchali</I> Flowers},
    journal = {Research Journal of Pharmacology},
    volume = {6},
    number = {5},
    pages = {62-70},
    year = {2012},
    issn = {1815-9362},
    doi = {rjpharm.2012.62.70},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9362&doi=rjpharm.2012.62.70},
    author = {M. Ekramul,M. Atowar,M. Abdullah A.,Ishrat,J.A.M. Samir,M. and},
    keywords = {Antioxidant,analgesic,anti-inflammatory,Nymphaea nouchali,DPPH,Bangladesh},
    abstract = {<I>Nymphaea nouchali </I>leaves are used in folk medicine for the treatment of various disorders. In order to evaluate the actions of this plant, studies were performed on antioxidant, analgesic and anti-inflammatory activities. The Methanolic extract of <I>Nymphaea Nouchali</I> Flowers (MNNF) was evaluated for anti-inflammatory activity using carrageenan induced hind paw edema model whereas hot plate, writhing and formalin tests was carried out for analgesic activity. Total phenolic and flavonoids content, scavenging of 1, 1-Diphenyl-2- Picrylhydrazyl (DPPH) radical, peroxynitrate (ONOO<SUP>-</SUP>) as well as inhibition of total ROS generation were used to evaluate antioxidant potential of MNNF. The extract MNNF at the dose of 100 and 200 mg kg<SUP>-1</SUP>, produced a significant (p&lt;0.05) increase in pain threshold in hot plate method whereas significantly (p&lt;0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. The same ranges of doses of MNNF caused significant (p&lt;0.05) inhibition of carrageenan induced paw edema after 4 h in a dose dependent manner. In DPPH, ONOO<SUP>-</SUP> and total ROS scavenging method, MNNF showed good antioxidant potentiality with the IC<SUB>50</SUB> value of 10.33&plusmn;1.02, 20.16&plusmn;0.61 and 31.72&plusmn;0.48 &#956;g mL<SUP>-1</SUP>, respectively. The findings of the study suggested that <I> Nymphaea nouchali </I> has strong analgesic, anti-inflammatory and antioxidant effects, conforming the traditional use of this plant for inflammatory pain alleviation to its antioxidant potentiality.}
    }