@article{MAKHILLRJP20126112473,
    title = {Anti-microbial Activity and Biochemical Constituents of Two Edible and Medicinal Mushrooms of Mid-Western, Uganda},
    journal = {Research Journal of Pharmacology},
    volume = {6},
    number = {1},
    pages = {4-11},
    year = {2012},
    issn = {1815-9362},
    doi = {rjpharm.2012.4.11},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9362&doi=rjpharm.2012.4.11},
    author = {Immaculate and},
    keywords = {Fractions,anti-microbial compounds,Termitomyces sp.,bioactive,bacteria,Uganda},
    abstract = {As a contribution to a search of alternative drugs against emerging resistant pathogenic strains, this study aimed at determination of anti-microbial activity and identification of the potential bioactive compounds in two medicinal mushrooms (<I>Termitomyces</I> sp. (Bunyanaka) and <I>Termitomyces microcarpus</I>) used for treating coughs, boils, sore throat or tonsillitis. To achieve this target, the fractions were obtained from petroleum ether and methanol crude extracts and tested <I>in vitro</I> for anti-microbial activities against selected bacterial strains and a fungus. The bioactive compounds were identified using GC-MS. Gram positive bacteria were more sensitive than gram negative ones. Isolated fractions had activity at a MIC value of 3.13-200 &#956;g mL<SUP>-1</SUP>. Similarly, petroleum ether fractions had high activity than methanol ones. Interestingly, <I>Pseudomonas aeruginosa</I> was more sensitive to <I>Termitomyces</I> sp. fractions with a MIC value of 50-75 &#956;g mL<SUP>-1</SUP>. Several bioactive compounds were identified in the mushrooms. Further studies should be done to elucidate these compounds as a contribution towards drug development.}
    }