@article{MAKHILLRJP20115212457,
    title = {Bioavailability and Pharmacokinetics of Ibafloxacin Following Intravenous and Intramuscular Single-Dose Applications in Chickens},
    journal = {Research Journal of Pharmacology},
    volume = {5},
    number = {2},
    pages = {22-26},
    year = {2011},
    issn = {1815-9362},
    doi = {rjpharm.2011.22.26},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9362&doi=rjpharm.2011.22.26},
    author = {M.A.},
    keywords = {infection,chickens,Ibafloxacin,bioavilability,pharmacokinetics,Egypt},
    abstract = {The single-dose pharmacokinetics of ibafloxacin was studied 
  in clinically normal chickens after intravenous and intramuscular administration 
  of 7.5 mg of ibafloxacin kg&oline;<SUP>1</SUP> of body weight. Ibafloxacin concentrations 
  were determined by Microbiological assay method. The distribution and elimination 
  half-lives were 0.261 and 5.87 h, respectively. Steady-state volume of distribution 
  and clearance of ibafloxacin after intravenous administration were 4.09 L kg&oline;<SUP>1</SUP> 
  and 0.519 L kg&oline;<SUP>1</SUP> h&oline;<SUP>1</SUP>, respectively. Following 
  intramuscular administration, ibafloxacin achieved maximum plasma concentration 
  of 1.06 &#956;g mL&oline;<SUP>1</SUP> achieved after maximum time of 1.3 h post-injection. 
  The systemic bioavailability after intramuscular injection was 79.6% and the 
  extent of serum protein binding was 27.04%. Ibafloxacin could be useful in the 
  treatment of systemic infections in chickens after specific assessment of susceptible 
  microorganisms.}
    }