@article{MAKHILLRJP20104112434,
    title = {Comparative <I>in vitro</I> Study of Relative Anesthetic Potency of Ropivacaine and Lidocaine},
    journal = {Research Journal of Pharmacology},
    volume = {4},
    number = {1},
    pages = {1-4},
    year = {2010},
    issn = {1815-9362},
    doi = {rjpharm.2010.1.4},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9362&doi=rjpharm.2010.1.4},
    author = {Marilena,Kyriakos,Nikolaos,Theodora and},
    keywords = {sciatic nerve,in vitro,comparative study,ropivacaine,Lidocaine,compound action potentials},
    abstract = {The purpose of this experimental study was the accurate evaluation of relative anesthetic potency of lidocaine and ropivacaine electrophysiologically <I>in vitro</I>. Total 18 sciatic nerves from male Wistar rats weighing between 250-300 g were used. The sciatic nerves were dissected from the spinal cord to the knee, immersed in a standard saline solution and mounted across a three-chambered recording bath. The 18 nerves were divided in 2 groups. In group A 300 &#956;L of ropivacaine 0.2% and in group B 300 &#956;L of lidocaine 0.2% were applied. Each local anesthetic remained in the perfusion chamber until the reduction of the compound action potential reach the 50% of the originally measured value (IT<SUB>50</SUB>) and this reduction was accepted as establishment of anesthesia. Ropivacaine 0.2% was proved to be of statistically less potency regarding the establishment of anesthesia compared to lidocaine 0.2% (p = 0.000497) in the pH of 7.4. The IT<SUB>50</SUB> for the nerves, which came in direct contact with ropivacaine 0.2% was estimated to be 25.28&plusmn;7.61 min (n = 9). As for lidocaine 0.2% the IT50 was estimated to be 11.78&plusmn;4.18.}
    }