@article{MAKHILLRJP20093112424,
    title = {Selective <I>In vitro </I>Cytotoxic Effects of Piroxicam and Mefenamic Acid on Several Cancer Cells Lines},
    journal = {Research Journal of Pharmacology},
    volume = {3},
    number = {1},
    pages = {15-18},
    year = {2009},
    issn = {1815-9362},
    doi = {rjpharm.2009.15.18},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9362&doi=rjpharm.2009.15.18},
    author = {M.N. Somchit,S. Faizah,A. Zuraini,H.M. Khairi,A.H. Hasiah and},
    keywords = {Piroxicam,mefenamic acid,cancer,NSAIDs,HCT 116,CaCo-2},
    abstract = {Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are heterogenous group of compounds used to cure and prevent inflammation. It was demonstrated that NSAIDs has the ability to inhibit the viability of colon cancer cells <I>in vitro</I>. We investigated the effects of Piroxicam and mefenamic acid on the viability of 4 cancer cell lines in which 2 of them are colon cancer cell lines (HCT 116 and CaCo-2). Cell viability was determined using MTT assay. Both NSAIDs was observed to markedly decrease  the  cell  viability  of  both  cell  lines (HCT 116 and CaCo-2). Piroxicam was statistically more cytotoxic towards the cancer cell lines when compared to mefenamic acid. However, the cytotoxic effect of NSAIDs was less potent on breast cancer cells (MCF-7) and liver cancer cells (Hep G2).  In conclusion, piroxicam and mefenamic acid showed selective cytotoxic effects against colon cancer cells but not against liver or breast cancer cells.}
    }