@article{MAKHILLRJP20082112410,
    title = {Detection of Tylosin Residue Levels Following Intramuscular Injection in Desert Sheep},
    journal = {Research Journal of Pharmacology},
    volume = {2},
    number = {1},
    pages = {1-3},
    year = {2008},
    issn = {1815-9362},
    doi = {rjpharm.2008.1.3},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9362&doi=rjpharm.2008.1.3},
    author = {Samia A.A. Hassan,Sania A.I. Shaddad,I.B. ElTayeb,M.A. Omer,M.H. Al-Nazawi and},
    keywords = {Residue,intramuscular,tylosin,sheep},
    abstract = {A total of 12 healthy desert sheep were injected intramuscularly with multiple doses of 5 g kg<SUP>-1</SUP> tylosin. Samples were collected at time 1, 3, 7 and 10 days after drug administrations. Tylosin was detected using microbiological method. Tylosin concentrations in different tissue were detected. High concentration of 61.78±5.83,  315.97±73.07  and  3956±645.59  µg g<SUP>-1</SUP> were  detected in liver, kidney and muscle, respectively at day 1. The highest concentrations of 19185±2966.9 µg g<SUP>-1</SUP> were noted at the site of injection at day 1 and persisted for 10 days. Low concentrations of 1.00, 1.5±0.24 and 5.22±0.20 µg g<SUP>-1</SUP> were noted in the liver, kidney and muscle at day 10, respectively. It is suggested that high tissue levels may create a reservoir of drug from which drug was released slowly into the circulation.}
    }